Quinacrine and Berberine as Antiviral Agents against Dengue and Zika Fever: In Silico Approach- Crimson Publishers
Quinacrine and Berberine as Antiviral Agents
against Dengue and Zika Fever: In Silico Approach by Vivek Srivastava in OpenAccess Biostatistics & Bioinformatics: Crimson Publishers- Open Access
Biostatistics & Bioinformatics journals
TDengue and Zika fever are mosquito-borne viral
diseases that have rapidly spread in all over world. Currently there are no
specific drugs for DENV and ZIKV infection. The recent outbreak of these
viruses realized that there are major health risks, demands an enhanced surveillance
and a need to develop novel drugs against them. Non-structural proteins NS5 and
NS3 are essential for the replication of the flavi-viral RNA genome. Therefore
its inhibition could be considered as a useful strategy for treatment of DENV
and ZIKV infection. Quinacrine and Berberine had been docked with
NS5-methyltransferase of Dengue virus and NS3 protein of ZIKV using Auto dock
4.2 tools. Quinacrine and Berberine showed binding affinity -6.83kcal/mol and
-6.22kcal/mol with NS5-methyltransferase and -7.32kcal/mol and -8.03kcal/mol
with NS3 protease of ZIKV, respectively. Observations discussion in review will
be useful in designing single drug against both virus infections.
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