Formulation & Evaluation of Sustained Release
Matrix Tablet of Repaglinide by Gaurav Agarwal in Open Access Biostatistics& Bioinformatics
The aim of present is to develop & evaluate
Sustained release matrix tablet of Repaglinide. Repaglinide is an effective
antihyperglycemic. But owing to its shorter half life it needs frequent
administration. In present study, an attempt has been made to develop Sustained
release matrix tablet of Repaglinide thereby reducing its frequency of
administration & other dose related side effects. Various grades of HPMC
(K4M, 100M & 15M) were used as hydrophilic matrix polymer. Croscarmellose
was used as swelling agent. Total 9 formulations were prepared in trial
batches. The formulation was evaluated for various pre compression & post
compression parameters. All the formulations showed compliance with the
pharmacopoeial standards. On the basis of evaluated parameters formulation F9
was considered to be the best one. Formulation F9 containing polymer HPMC
showed 99.15% in- vitro drug release profile. The release data for formulation
F9 was fitted to various mathematical models like zero order, first order,
Krosmeyer Peppas & Higuchi model. It was observed that drug follows zero
order & Higuchi model.
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