Tuesday, 1 October 2019

Sunday, 29 September 2019

String Matching in DNA Databases- Crimson Publishers

String Matching in DNA Databases by Yangjun Chen in Open Access Biostatistics & Bioinformatic: Crimson Publishers- Crimson Publishers Open Access Journal


The recent development of next-generation sequencing has changed the way we carry out the molecular biology and genomic studies. It has allowed us to sequence a DNA (Deoxyribonucleic acid) sequence at a significantly increased base coverage, as well as at a much faster rate [1]. This facilitates building an excellent platform for a whole genome sequencing, and for a variety of sequencing-based analyses, including gene expressions, mapping DNA-protein interactions, whole-transcriptome sequencing, and RNA (Ribonucleic acid) splicing profiles. For example, the RNA-Seq protocol [2], in which processed mRNA is converted to cDNA and then sequenced, is enabling the identification of previously unknown genes and alternative splice variants. The whole-genome sequencing of tumour cells can uncover previously unidentified cancer-initiating mutations.

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Tuesday, 24 September 2019

Bioinformatics: An Introduction- Crimson Publishers

Bioinformatics: An Introduction by Nidhi Mishra in Open Access Biostatistics & Bioinformatic: Crimson Publishers- Open Access Biostatistics & Bioinformatics journals


An unprecedented revolution has been observed in science with recent technological advances, which have provided a large amount of “omic” data. The crescent generation and availability of this information available in public databases were, and still are, a challenge for professionals from different areas. However, what is the challenge? In biology, the main challenge is to make sense of the enormous amount of structural data and sequences that have been generated at multiple levels of biological systems. Still, in bioinformatics, development of tools is necessary (statistical and computational) capable of assisting in understanding the mechanisms underlying biological questions in the study. Besides, if we consider the complexity of science, this is a highly reductionist view. The era of a “new biology” emerges accompanied by the birth/development of other sciences, such as bioinformatics and computational biology, which have an integrated interface of molecular biology.

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Friday, 13 September 2019

Students’ Home Activities and Academic Performance in Economics in Senior Secondary School II in Isoko South Local Government Area of Delta State- Crimson Publishers

Students’ Home Activities and Academic Performance in Economics in Senior Secondary School II in Isoko South Local Government Area of Delta State by Kingsley Akarowhe in Open Access Biostatistics & Bioinformatic- Crimson Publishers: Bioinformatics Open Access Journals



This study investigated the influence of students’ home activities on their academic performance in Economics in senior secondary school II in Isoko South Local Government Area of Delta State. Three research questions were answered in the study and three null hypotheses were tested at .05 level of significance. The population of the study consisted of 1,130 senior secondary school II in Isoko South Local Government Area of Delta State. A sample size of 113 students was adopted; this was 10 percent of the entire population. A 21 structured questionnaire was used to elicit responses from the respondents (students). The questionnaire was face-validated by experts in Faculty of Education, University of Uyo. Cronbach’s Alpha Technique was used in determining the reliability of the instrument and a correlation coefficient of 0.76 was obtained.

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Friday, 23 August 2019

An RGB-D Camera-based Travel Aid for the Blind- Crimson Publishers

An RGB-D Camera-based Travel Aid for the Blind by Mu-Chun Su in Open Access Biostatistics & Bioinformatic: Crimson Publishers- Crimson Publishers Open Access Journal

In this paper, we present the application of an RGB-D camera in developing a travel aid for the blind or visually impaired people. The goal of the proposed travel aid is to provide the user with information about obstacles along the travelled path so he or she may walk safely and quickly in an unfamiliar environment. The performance of the travel aid greatly depends on whether the ground plane can be successfully detected. In this paper, we present a new approach to detecting the ground plane from a depth image. Two different experiments were designed to test the performance of the proposed travel aid.

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Sunday, 30 June 2019

Escherichia coli Genome-Scale Metabolic Models Could Guide Construction of Proof-of-Principle Strains- Crimson Publishers


Escherichia coli Genome-Scale Metabolic Models Could Guide Construction of Proof-of-Principle Strains by Bashir Sajo Mienda in Open Access Biostatistics & Bioinformatic- Crimson Publishers: Bioinformatics Open Access Journals



Escherichia coli genome-scale metabolic models (GEMs) have been published with ability to predict metabolic engineering capabilities that could be consistent with experimental measurements. However, the GEMs have limited scope, and the models are of two types, metabolism models (M-model), and metabolism and gene expression (ME-model) that could guide the constructions of proof-of-principle strains of particularly E. coli bacterium that may find applications in metabolic engineering strategies, synthetic biology [1], and beyond. GEMs have been clearly established to be capable of predicting metabolic engineering capabilities and could sometime lead to biological discoveries for missing reactions and/or missing gene functions [2-4]. In addition, systems metabolic engineering has proof useful with the use of GEMs where time consuming experimental trial and error was shortened by predicting engineering strategies using GEMs. Although sometimes prediction could fail to agree with experimental data, but in that circumstances missing knowledge can be uncovered and gaps in the reconstruction can therefore be bridged leading to novel biological discoveries [3,4].
https://crimsonpublishers.com/oabb/fulltext/OABB.000518.php

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Thursday, 20 June 2019

Bio-Informatics & Bio-Statistics for the Third Millennium- Crimson Publishers

Bio-Informatics & Bio-Statistics for the Third Millennium by Eduard Babulak* in Open Access Biostatistics & Bioinformatics-Crimson Publishers: Bioinformatics OpenAccess Journals



Given the continuous increase of computation, the applied informatics biostatistics play essential role in collecting and processing enormous large amount of data generated by biological experiments, environment pollution, climate change, human health. Biostatistics is the application of statistics to a wide range of topics in biology [1]. Bioinformatics is both an umbrella term for the body of biological studies that use computer programming as part of their methodology, as well as a reference to specific analysis “pipelines” that are repeatedly used, particularly in the field of genomics [2]. The clean environment and healthy food supply to people all over the world is one of the most critical challenges for all mankind. The governments in developing countries are under enormous pressure to provide proper medical services, supply of healthy food, drinkable water, as well as creating opportunities to farm and harvest.

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