Showing posts with label Bioinformatics. Show all posts
Showing posts with label Bioinformatics. Show all posts

Friday, 26 July 2024

Enhancing Learning with ChatGPT: A Transformative Educational Companion



In recent years, the integration of Artificial Intelligence (AI) technologies into educational settings has opened up new possibilities for personalized and interactive learning experiences. Among these technologies, ChatGPT, an advanced language model developed by OpenAI, has emerged as a promising educational companion. ChatGPT utilizes Natural Language Processing (NLP) algorithms to engage in conversational interactions, provide feedback, and deliver personalized learning materials. This academic review explores the potential of leveraging ChatGPT as a transformative educational companion, examining its applications, benefits, challenges, and implications for teaching and learning.

Applications of ChatGPT in Education

ChatGPT offers a wide range of applications in education, ranging from providing instant feedback on student responses to facilitating interactive learning experiences. As a conversational agent, ChatGPT can engage students in dialogues on various topics, clarify concepts, and answer questions in real-time. Additionally, ChatGPT can generate personalized learning materials, such as summaries, quizzes, and study guides, tailored to individual students’ needs and preferences. Furthermore, ChatGPT can assist educators in tasks such as lesson planning, content creation, and assessment design, enhancing instructional efficiency and effectiveness.

 Read More About This Article: 10.31031/OABB.2024.03.000570

Read More About our Journal: https://crimsonpublishers.com/oabb/


Thursday, 25 July 2024

Utilizing P-Scores to Quantify Excess Mortality During the COVID-19 Pandemic


Death numbers have been reported since the beginning of the COVID-19 pandemic, but they may not represent the true impact of the pandemic. Excess mortality is a robust metric and a critical indicator of the impact of the COVID-19 pandemic. P-scores provide estimates of excess mortality and have been widely utilized in many COVID-19 studies around the world. P-score analyses have revealed more pandemic-associated deaths than official COVID-19 statistics alone. While a substantial proportion of excess mortality during the COVID-19 pandemic can be directly attributed to the virus infection itself, mortality from major non-infectious chronic diseases substantially contributed to an increase in excess mortality P-scores. Thoughtful considerations of approaches to defining counterfactual mortality are important for ensuring the validity of calculated P-scores.

 Read More About This Article: 10.31031/OABB.2024.03.000569

Read More About our Journal: https://crimsonpublishers.com/oabb/

Wednesday, 24 July 2024

The First Experience of Tomographic Representation of an ECG-Signal


At present, spectacular progress is achieved in the development of probabilistic approach to the basic principles of quantum mechanics (for instance, see [1]). This approach is based on tomographic representation of density matrix and the Wigner function [2,3], yielded by the Radon transform [4]. The probabilistic approach made it possible to apply the methods of quantum mechanics in description of various signals. The most comprehensive description of this method is given in [5]. Especially interesting are the attempts to use the tomographic approach to transform and analyze the medical signals [6,7]. When processing such signals, the Fourier transform is widely used, representing the signal as a function of the frequency ω. This transform is currently a common tool in the analysis of Electrocardiograms (ECGs). The tomographic transformation makes it possible to represent the signal as a positively defined function that simultaneously depends on both time and frequency. Recently, the tomographic representation was applied for processing some biological signals [8,9]. These studies were carried out to evaluate new perspectives that open up when analyzing a human ECG using tomographic representation.

Tomographic Representation

The tomographic representation can be introduced as a generalization of the Wigner function to a positive definite distribution [10]. A rigorous description of this mathematical transformation is given in [5], and a detailed description of its application to the analysis of some biological signals is given in [8,9]. Here we will give a brief description of the essence of the tomographic representation.

Read More About This Article: 10.31031/OABB.2024.03.000568

Read More About our Journal: https://crimsonpublishers.com/oabb/

Tuesday, 23 July 2024

Managing Pandemic Disasters: A Resource-Based Analysis


Healthcare crises are well-known phenomena that occur and are highly disruptive. Consider, for example, Covid19 and other pandemics, wars, multi-casualty natural disasters, industrial disasters, etc. Healthcare systems in Brazil, Spain, Italy, and more around the world collapsed due to the lack of a clear methodology for handling such crises. Following a largescale value creation project with a large medical center we developed a resource-based methodology to cope with three healthcare crisis scenarios: “Peace”, “War” and “Tsunami”.

We identified three load/capacity scenarios for hospitals: “Peace”, “War” and “Tsunami”. The Peacetime scenario is the normal overload situation in a hospital. Figure 1 during “Peace” times, hospitals are usually 10%-20% short in resources. To overcome bottlenecks, managers apply evolutionary methods such as constraint management [1], the complete kit concept, etc. This is the normal condition in hospitals where there are fluctuations in supply and demand. Bottlenecks in this situation are typically medical crews: senior physicians and experienced nurses.

Read More About This Article: 10.31031/OABB.2024.03.000567

Read More About our Journal: https://crimsonpublishers.com/oabb/

Monday, 22 July 2024

Artificial Cell Membranes as Bioinformation Hubs: Unraveling Therapeutic Networks through Nano-Informatics


In this brief the innovative realm of artificial cell membranes as bioinformation hubs, specifically focusing on their role in creating therapeutic networks, is proposed. The integration of advanced nanotechnologies, bioinformatics, cheminformatics, and medical informatics has paved the way for the development of in silico tools that facilitate the simulation of interactions and mechanisms of toxicity in therapeutic products, particularly in drug delivery nanosystems. Various specialized cloud platforms incorporate libraries of diverse nanomaterials with comprehensive morphological and biological data, enabling correlation with potential adverse effects. Such tools prove invaluable in guiding the pharmaceutical industry in the development of innovative therapeutical formulations and aiding regulatory agencies in evaluating decision-making nanoplatforms. Finally, in this opinion-article we support the idea the cell membranes could be considered as bioinformation hubs and artificial pharmaceutical nanoplatforms.

 Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000566.php

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Friday, 19 July 2024

The Weird Human Sences


Opinion

Well Known Facts

It is rather strange that the nature gave only 5 senses to the human beings. As everybody

knows these senses are: Dactyl -to feel the touch and vibrations, Smell-to feel odors, aromas,

Taste-to feel the tastes, Vision-to view the environment and feel the light and colors, Hearing-

to hear the sounds and noises.

 From physical point of view

The dactyl feeling is a transmission from sensitive nerves of our hands (predominantly,

but also by skin, body and legs) to the brain, where these feelings are transformed into brain

impulses. The range of this sense is between 10-15Hz to more than 20 000Hz depending on

the amplitudes of the vibrations. By this sense is also possible to feel temperature variations

is a very narrow band (-50 0-60 0C to +70 0-80 0C). The taste feeling covers: bitter, sweet, hot,

sour and salty and a small amount of combinations - at all 5 tastes.

Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000565.php

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Thursday, 20 June 2024

Global Social and Economic Impact of SARS- CoV-2 Pandemic on Industry Sectors


Abstract

On December 31, 2019, the Chinese government formally proclaimed the identification of a new type of coronavirus (SARS-CoV-2) as the etiological source of a critical respiratory disease in Wuhan city, Hubei Province. Over the next few weeks, SARS-CoV-2 introduced a global pandemic as formally declared by the WHO on March 11th, 2020, with inveterate cases and deaths in more than 212 countries leading to exceptional social and economic consequences.

Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000556.php

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Friday, 14 June 2024

Genomics of Newly Discovered Leprosy Pathogen: Mycobacterium lepromatosis and Its Geographic Isolation in Mexico


Overview

Leprosy is a chronic dermatologic infection that has plagued human populations for thousands of years. Mycobacterium leprae, the etiological agent for leprosy, has puzzled scientists since its identification by Hansen in 1873 [1]. Leprosy is one of the leading causes of treatable neuropathy [2]. It has been affecting mankind since the earliest historically recorded identification and far beyond (2000 B.C, in ancient Indus civilization) [3]. Leprosy is also one of the earliest recognized diseases which have a proven association with the bacterial pathogen, M. leprae [3]. In 2008, a new bacterium, M. lepromatosis was discovered in Mexico which was also reported to cause leprosy [4]. M. lepromatosis was found to be associated with a typical severe form of lepromatous leprosy (LL), called Diffuse Lepromatous Leprosy (DLL) which is usually seen in the Americas [5-7]. DLL is characterized by an unusual form of immune reaction against the pathogen, called Lucio’s phenomenon, characterized by diffuse, non-nodular cutaneous infiltration with sharply demarcated skin lesions, which often gets infected to result in life threatening situations [8,9].

Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000553.php

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Thursday, 13 June 2024

COVID-19 Epidemic: China and ex-China

 


Abstract

Here we report the current COVID-19 epidemic in terms of mortality and recovery compared to the confirmed patient population of provinces in China as well as countries outside of China. Data was obtained from the Center for System Science and Engineering (CSSE) by Johns Hopkins University (JHU) and was plotted in log-log charts. For China, mortality dropped as low as 0.08% but then converged to a band of 1%-5%, with the median value of 1.1% as of March 9th, 2020. For countries outside of China, mortality dropped to a low of 0.2% with a median value of 2.4% as of March 9th, 2020. This difference was statistically significant with p=0.0057.A bi-modal distribution in mortality was observed for both China and countries outside of China, which would concur with reports mentioning two possible strains of the SARS-CoV-2 virus. China exhibited a median recovery rate of 95.0% with the lowest being Hubei province with a recovery rate of 57%. Outside of China, the median recovery rate was 10.7% and was significantly lower than that of China, p <0.0001, t-test. Distribution-wise, both China and countries outside of China were observed to be similar. As of now, the spread of COVID-19 in countries outside of China are showing properties more similar to that of Hubei–the epicenter of COVID-19 epidemic in China.

Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000552.php

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Tuesday, 16 February 2021

Detection of protein complexes in blood plasma synthesized by malignant glioma cells and their microenvironment by dynamic light scattering depending on the degree of the blood-brain barrier permeability_Crimson Publishers

Detection of protein complexes in blood plasma synthesized by malignant glioma cells and their microenvironment by dynamic light scattering depending on the degree of the blood-brain barrier permeability by Gridina NYa in Open Access Biostatistics & Bioinformatics

In the blood plasma of patients with malignant gliomas of the brain by method dynamic light scattering protein complexes with diameter of more than 150nm were detected, indicating increased permeability of the blood brain/tumor (BBTB) and blood-brain (BBB) barriers. The results of these studies are taken as the basis for the development of the express method for determining the increased permeability of the BBTB and BBB in neurosurgical patients. The method can be used at a certain stage of chemotherapy for patients with malignant gliomas of the brain, depending on the permeability of the BBTB and BBB.

https://crimsonpublishers.com/oabb/fulltext/OABB.000551.php

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Modeling of Capture Fisheries and Effectiveness of the Current Gear Restriction: The Case of Lake Tana, Ethiopia_Crimson Publishers

 Modeling of Capture Fisheries and Effectiveness of the Current Gear Restriction: The Case of Lake Tana, Ethiopia by Erkie A in Open Access Biostatistics & Bioinformatics

Following the exponentially increased demand for fishes, magnificent number of individuals are participated in various stages of capture fisheries in order to improve their livelihood. However, in Lake Tana fisheries, regulations related to gear restriction (fishing net and mesh size), destructive way of fishing, closing of spawning season and site, and amount of harvest are a loosely (almost not) regulated. This is attributed to weak institutions that have no incentives for fishers to manage efficiently in a way that maximized their present and future benefits. As a management framework, fishing gear restriction reduces the burden on the open access fishery and endangered species. On the other hand, ITQs encourage increased responsibility and accountability by quota owners for management and enhancement of the fishery resource. In this regard, ITQs is more efficient than gear restriction because of it creates sense of ownership and its flexibility in providing stable and profitable market.

https://crimsonpublishers.com/oabb/fulltext/OABB.000550.php

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Comparison of Tuberculosis, Measles, Poliomyelitis and Rubella on Children Aged Less than 15 in a Poor Country: Case of the Republic of Pakistan_Crimson Publishers

 Comparison of Tuberculosis, Measles, Poliomyelitis and Rubella on Children Aged Less than 15 in a Poor Country: Case of the Republic of Pakistan by İlker Etikan in Open Access Biostatistics & Bioinformatics



We compared Measles, Tuberculosis, Poliomyelitis and Rubella infectious diseases in Pakistan on children aged less than 15 years from 2013 to 2018. We collected the registered cases of each disease per years at the World Health Organization (WHO) and at the United Nation International Children Emergency Fund (UNICEF) website and we used SPSS program to calculate descriptive statistics and plot graphics. We find out that over the past six years, among the four infectious diseases studied, Tuberculosis and Measles were the most present among children aged fewer than 15, their mean over the years was respectively 34430.50 and 20107.50, and their percentage was around 50% Of the whole studied diseases. Rubella and Poliomyelitis were the less infectious disease present among children aged under 15 in Pakistan from 2013 to 2018, their mean over the years was respectively 178.35 and 114.28, and their percentage was around 1% of the whole studied infectious diseases. Furthermore, Away from Poliomyelitis which curve was mostly decreasing over the last six years, all the three other diseases, Tuberculosis, Measles and Rubella had a curve mostly increasing over the last six years.

https://crimsonpublishers.com/oabb/fulltext/OABB.000549.php 

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Friday, 22 January 2021

The Stupidity of Criticism_Crimson Publishers

The Stupidity of Criticism by James F Welles in Open Access Biostatistics & Bioinformatics

Fortunately for sensitive egos, people do not have to acknowledge criticism in order to react to it. Corrective reactions may be undertaken without anyone admitting anything was wrong. Demonstrating the power of negative thinking, the accompanying verbal response to warranted but unwelcome criticism is usually to the effect that, “We have not done anything wrong and will not do it again”.

https://crimsonpublishers.com/oabb/abstract/OABB.000548.php

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The Stupidity of Communications_Crimson Publishers

 The Stupidity of Communications by James F Welles in Open access Biostatistics & Bioinformatics


In the formation and transformation of culture and its transmission across generations, communication is paramount. In fact, learning, unlearning and relearning are all communicative processes fundamental to the development and existence of culture [1]. This is not a uniquely human phenomenon, as many amniotic species depend upon their considerable learning capabilities in the development of their social organization and general behavior. While this basic cultural process is part of our biological heritage [2], language gives human culture its distinctive flair. In developing the cultural capacity for stupidity to human desiderata, language proved to be a most effective mechanism in that it both inhibits and subverts awareness. It is language which provides us with our basic misperceptions, which culture then embellishes and disseminates. Thus, self-unawareness is promoted when language permits us to misinterpret embarrassing events into socially acceptable contexts. Although sense organs give us our first impressions of our environment, words fix our attitudes, direct the process of data selection and strongly influence the misinterpretation of information so that we may misconstrue experiences.

https://crimsonpublishers.com/oabb/pdf/OABB.000547.pdf 

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Wednesday, 6 January 2021

Portfolio Analysis in Finance Mathematics_Crimson Publishers

 Portfolio Analysis in Finance Mathematics by DS Hooda in Open access Biostatistics & Bioinformatics


In the present paper a brief account of the deterministic model due to Marko is given and the concept of mean variance efficient frontier to find all efficient portfolios that maximize the expected returns and minimize the variance are introduced. Some measures of portfolio analysis based on entropy meanvariance frontier and maximum entropy model in risk sharing are proposed and studied.

https://crimsonpublishers.com/oabb/pdf/OABB.000546.pdf

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Friday, 11 December 2020

Meta-Analysis of a Very Low Proportion Through Adjusted Wald Confidence Intervals_Crimson Publishers

Meta-Analysis of a Very Low Proportion Through Adjusted Wald Confidence Intervals by Afreixo V in Open Access Biostatistics & Bioinformatics


In this paper we will discuss the meta-analysis of one low proportion. It is well known, that there are several methods to perform the meta-analysis of one proportion, based on a linear combination of proportions or transformed proportions. However, in the context of a linear combination of binomial proportions has been proposed some approximate estimators with some improvements on low proportion estimation. In this paper we will show, with a simple adaptation, the possible contribution of several approximate adjusted Wald confidence intervals (CIs) for the meta-analysis of proportions. In the context of low proportions, a simulation study scenario is carried out to compare these CIs amongst themselves and with other available methods with respect to bias and coverage probabilities, using the fixed effect or the random-effects model. 

https://crimsonpublishers.com/oabb/abstract/OABB.000545.php

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Tuesday, 3 November 2020

Stupidity and the Sexes_Crimson Publishers

Stupidity and the Sexes by James F Welles in Open Access Biostatistics & Bioinformatics


Unfortunately, the cognitive basis for much social stupidity is not discrimination based on ability but the human tendency to generalize behavior of differentiated members of a group into the form of a representative stereotype. This streamlines social decisions, as individual variation can be ignored, and reactions keyed to specific characteristics deemed definitive for behavioral inter-action. However, the loss to stereotyping is obvious: individuals are raised up or put down not due to their individual abilities but because they are lumped into a linguistic category. Women, for ex-ample, have been universally and eternally victimized by stereotyping [1] to the degree that 400 years ago expert on females, Cardinal de Richelieu concluded “Intellect in a woman is unbecoming” [2].

https://crimsonpublishers.com/oabb/abstract/OABB.000543.php 

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Review on Economics of Teff in Ethiopia_Crimson Publishers

Review on Economics of Teff in Ethiopia by Fikadu, Asmiro Abeje in Open Access Biostatistics & Bioinformatics

Teff is widely cultivated throughout Ethiopia as a staple cereal crop, which appears in everyone’s dishes of everyday life. With a gluten free and high nutrition values; teff could be the next super-grain and Injera could be the next super-food in the globe. Teff productions in terms of cultivated area and number of producers are incredibly increases over the last 14 years. Teff is the second most important cash crop and generating about 500 million USA dollar incomes per year for local farmers. Apart from this, teff producing farmers are highly depending on the behavior of the other teff producing farmers who spatially closed. Moreover, Teff straw is produced in the largest quantities estimating about 6.93% of the total quantity of cereal crop’s straw produced in the country; this helps to address the insufficient animal feed supply for animal production and productivity improvement through enhancing its palatability. The exports of teff in terms of injera in 2015 were estimated at around 10 million US dollar, and the main injera global market outlets were North America, Middle East, and Europe. Among several teff production constraints, technical inefficiency has a leading one. Due to the technical inefficiency of teff production; about 0.4ton/ha grain yield gap between the expected maximum potential and the actual teff grain yield. Teff grain yield gap is estimated about1.1 million ton in 2013 at countrywide due to technical inefficiency. Thus, this review as sought to ascertain of the economics of teff and put highlight policy implication for further assuring food security through teff.

https://crimsonpublishers.com/oabb/fulltext/OABB.000542.php

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Tuesday, 13 October 2020

Mental Energy in the Context of the General Theory of Information_Crimson Publishers

 Mental Energy in the Context of the General Theory of Information by Mark Burgin in Open access Biostatistics & Bioinformatics


 Many researchers wrote about mental energy, psychic energy and spiritual energy. However, still there is neither clear understanding nor welldefined characterization of these phenomena. Here we study these concepts based on the general theory of information, the structuration of the world in the form of the Existential Triad of the world and the existing psychological and philosophical knowledge about the brain, psyche and mentality on the individual level. The goal is to explain the structure of mentality and elaborate a consistent system of concepts related to mental energy.

https://crimsonpublishers.com/oabb/pdf/OABB.000540.pdf


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Fractal Applications in Bio-Nanosystems_Crimson Publishers

Fractal Applications in Bio-Nanosystems by S Sankararaman in Open access Biostatistics & Bioinformatics


We live in a world of high complexity in all means. The present article is an attempt to elucidate the potential of fractal analysis in understanding and quantifying the complexity. Of several methods of fractal analysis, we have used only the box counting and power spectral methods for explaining the potential of the technique. The application of fractal analysis in bio-nanosystems, thin films, are forensic science are exemplified though our own work.

https://crimsonpublishers.com/oabb/fulltext/OABB.000541.php

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